Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1011 | TK1011b | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 1 |
| 2 | 3TC+ AZT | 10 |
| 3 | None | 17 |
| 4 | 3TC+ D4T+ IDV | 1 |
| 5 | 3TC+ D4T | 56 |
| 6 | None | 23 |
| 7 | 3TC+ AZT | 47 |
| 8 | ABC+ D4T+ DDI+ EFV | 20 |
| 9 | None | 46 |
| 10 | 3TC+ AZT+ RTV+ SQV | 2 |
| 11 | None | 1 |
| 12 | 3TC+ D4T+ RTV+ SQV | 91 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, L19I, N37S, R41K, D60E, L63LP, I64V |
| >TK1011b| codons 1-99 PQITLWQRPLVTVKIGGQIKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYE QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | D67DE | V35T, T39IM, K49R, V60I, S68G, K101KQ, D121Y, K122E, I135T, Y144F, T165I, D177E, I178MV, T200I, Q207E, R211RK, V245Q, D250E, A272P, I274V, K277KR, L282C, T286A, I293V, P294A, E297K |
| >TK1011b| codons 1-322 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIEMEKEGKISRIGPENPYNTPI FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRFQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGVKVRQLCKCLRGAKALTEVVALTKEAE LELAENREILKEPVHGVYYDPS |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |