<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK1011 TK1011 Denmark 2001 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ IDV 1
2 3TC+ AZT 10
3 None 17
4 3TC+ D4T+ IDV 1
5 3TC+ D4T 56
6 None 23
7 3TC+ AZT 47
8 ABC+ D4T+ DDI+ EFV 20
9 None 36

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, L19I, N37S, R41K, D60E, I64V  
>TK1011| codons 1-99
PQITLWQRPLVTVKIGGQIKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYE
QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103KN   V35T, T39I, K49R, V60I, S68G, D121Y, K122KE, D123X, F130X, T131TP, Y144F, T165TI, D177E, I178M, T200I, Q207E, V245Q, D250E, A272P, I274V, K277R, L282C, T286A, I293V, P294A, E297K  
>TK1011| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIEMEKEGKISRIGPENPYNTPI
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
YEXFRKYTAXPIPSINNETPGIRFQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIGQHRIKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGVKVRQLCKCLRGAKALTEVVALTKEAE
LELAENREILKEPVHGVYYDPSKD

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005