Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1010 | TK1010a | Denmark | 2001 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 160 |
| 2 | AZT+ DDI | 191 |
| 3 | AZT | 52 |
| 4 | AZT+ 3TC | 21 |
| 5 | AZT+ 3TC+ IDV | 156 |
| 6 | IDV + Unknown | 13 |
| 7 | IDV+ ABC+ D4T | 60 |
| 8 | ABC+ D4T | 11 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10F | T12I, I13V, G16E, E35D, M36I, R41K, R57K, H69K, K70R, L89M |
| >TK1010a| codons 1-99 PQITLWQRPFVIVKIEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215V, K219Q | K101E, Y181C | E6D, V35T, T39A, E40D, V60I, K122E, D123S, I135K, K173S, Q174K, D177E, V179I, Q207A, R211N, H221HY, V245E, D250E, R284RK, T286A, E291D, V292I, I293V, P294T, V317A, P321PS |
| >TK1010a| codons 1-324 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICADMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII CQYMDDLYVGSDLEIGQHRTKIEELRAHLLNWGFVTPDQKYQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTDIVTLTEEAE LELAENREILKEPVHGAYYDSSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |