Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1009 | TK1009a | Denmark | 2002 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+ DDI | 4 |
| 3 | AZT+ 3TC | 69 |
| 4 | AZT+ 3TC+ IDV | 52 |
| 5 | 3TC+ D4T+ NFV | 30 |
| 6 | EFV + ABC + RTV | 95 |
| 7 | 3TC+ABC+AZT+LPV | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I | L10I, M36I, N37D, R41K, L63P, I64V, A71AV, I72V |
| >TK1009a| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEIDLPGKWKPKIIGGIGGFVKVRQYD QIPVEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215F | L34I, V35T, T39M, S48T, V60I, K122E, I142V, Q207E, R211K, L228H, V245Q, D250E, A272S, V276I, L282C, L283I, T286A, I293V, E297K |
| >TK1009a| codons 1-318 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKAITEICMELEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFFTPDKKHQKEPPFHWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKIKQLCKCIRGAKALTEVVPLTKEAE LELAENREILKEPVHGVY |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |