Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
TK1009 | TK1009 | Denmark | 2001 | HIV1 | D | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 56 |
2 | AZT+ DDI | 4 |
3 | AZT+ 3TC | 69 |
4 | AZT+ 3TC+ IDV | 52 |
5 | 3TC+ D4T+ NFV | 30 |
6 | EFV + ABC + RTV | 95 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, T215FL | L100LI, K103N | L34I, V35T, T39M, S48T, V60I, L109LI, K122E, I142V, Q207E, R211K, L228H, V245Q, D250E, A272S, K277R, L282C, L283I, T286A, I293V, I326M, Q332P, G335D | A327EQ |
>TK1009| codons 1-341 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKAITEICMELEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVIDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTPDKKHQKEPPFHWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVRQLCKCIRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLMEEIQKPGQDQWTYQI |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46ML | I13V, K14KR, E35D, M36I, R41K, K45KR, R57RK, L63P, H69KQ, A71AV, L89T |
>TK1009| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADDTVLEDINLPGKWKPRLIGGIGGFIKVKQYD QIPIEICGKKVIGTVLVGPTPVNIIGRNTLTQIGCTLNF |
References
Author | Title | Citation |
Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |