Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1009 | TK1009 | Denmark | 2001 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+ DDI | 4 |
| 3 | AZT+ 3TC | 69 |
| 4 | AZT+ 3TC+ IDV | 52 |
| 5 | 3TC+ D4T+ NFV | 30 |
| 6 | EFV + ABC + RTV | 95 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML | I13V, K14KR, E35D, M36I, R41K, K45KR, R57RK, L63P, H69KQ, A71AV, L89T |
| >TK1009| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADDTVLEDINLPGKWKPRLIGGIGGFIKVKQYD QIPIEICGKKVIGTVLVGPTPVNIIGRNTLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215FL | L100LI, K103N | L34I, V35T, T39M, S48T, V60I, L109LI, K122E, I142V, Q207E, R211K, L228H, V245Q, D250E, A272S, K277R, L282C, L283I, T286A, I293V, I326M, Q332P, G335D | A327EQ |
| >TK1009| codons 1-341 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKAITEICMELEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVIDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTPDKKHQKEPPFHWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVRQLCKCIRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLMEEIQKPGQDQWTYQI |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |