<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK1007 TK1007a Denmark 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ EFV 134

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K20R, M36I, R41K, H69K, L89M  
>TK1007a| codons 1-99
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, T215F D67G, K219Q K101E, G190S   E28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324E K154KN, F160FS
>TK1007a| codons 1-334
PISPIETVPVKLKPGMDGPKVKQWPLTGEKIKALTEICEEMEKDGKISKIGPENPYNTPV
FAIKKKGSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWNGSPAISQSSMTKILEPFRLQNPDIII
YQYMDDLYVSSDLEIGQHRAKIEELRAHLLSWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKALTDVVPLTKEAE
LELAENREILKDPVHGVYYDPAKELIAEIQKQGQ

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005