Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1006 | TK1006c | Denmark | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 17 |
| 2 | AZT+ DDI | 26 |
| 3 | AZT+ 3TC | 8 |
| 4 | AZT+ 3TC+ IDV | 26 |
| 5 | 3TC+ IDV+ D4T | 8 |
| 6 | None | 65 |
| 7 | 3TC+ D4T+ NFV | 69 |
| 8 | ABC+ EFV+ IDV+ RTV | 23 |
| 9 | ABC+ NFV+ EFV | 33 |
| 10 | ABC+ EFV+ LPV | 17 |
| 11 | ABC+ EFV | 30 |
| 12 | ABC+ NFV+ EFV | 4 |
| 13 | ABC+ NFV+ 3TC+ AZT+ RTV | 78 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | T27S, V35T, D123E, S162A, K166KR, Q174E, D177E, I178M, V179VM, T200A, E204R, Q207E, R211K, V245Q, K275R, K277Q, T286A, E291D, V292I, I293V, P294T, S322A |
| >TK1006c| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTRILEPFRKENPEMMI YQYMDDLYVGSDLEIGQHRAKIERLREHLLKWGFTTPDKKHQKEHPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVQQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LF | I13V, K20I, M36I, N37NY, R41K, K43KR, I64IM, H69K, K70KR, L89M |
| >TK1006c| codons 1-99 PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLEEIYLPGKWRPKMIGGIGGFIKVRQYD QILMEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |