<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK1006 TK1006c Denmark 2003 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 AZT 17
2 AZT+ DDI 26
3 AZT+ 3TC 8
4 AZT+ 3TC+ IDV 26
5 3TC+ IDV+ D4T 8
6 None 65
7 3TC+ D4T+ NFV 69
8 ABC+ EFV+ IDV+ RTV 23
9 ABC+ NFV+ EFV 33
10 ABC+ EFV+ LPV 17
11 ABC+ EFV 30
12 ABC+ NFV+ EFV 4
13 ABC+ NFV+ 3TC+ AZT+ RTV 78

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L10LF I13V, K20I, M36I, N37NY, R41K, K43KR, I64IM, H69K, K70KR, L89M  
>TK1006c| codons 1-99
PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLEEIYLPGKWRPKMIGGIGGFIKVRQYD
QILMEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N P225H T27S, V35T, D123E, S162A, K166KR, Q174E, D177E, I178M, V179VM, T200A, E204R, Q207E, R211K, V245Q, K275R, K277Q, T286A, E291D, V292I, I293V, P294T, S322A  
>TK1006c| codons 1-334
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTRILEPFRKENPEMMI
YQYMDDLYVGSDLEIGQHRAKIERLREHLLKWGFTTPDKKHQKEHPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVQQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQ

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005