Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1004 | TK1004c | Denmark | 2004 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ NFV | 59 |
| 2 | D4T+ EFV+ IDV+ RTV | 8 |
| 3 | D4T+ EFV+ IDV+ RTV+ 3TC | 79 |
| 4 | D4T+ IDV+ RTV+ 3TC | 8 |
| 5 | IDV+ RTV+ 3TC+ ABC+ AZT | 114 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12P, I15V, L19IT, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93L |
| >TK1004c| codons 1-99 PQITLWQRPLVPIKVGGQITEALLDTGADDTVLEDIDLPGKWKPRMIGGIGGFIKVRQYD QIPLEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36X, T39DE, S48T, V60I, K122E, D123NS, K166KR, K173A, D177E, I178IL, T200A, E204K, Q207N, R211K, V245NS, A272P, K277R, E291D, V292I, I293V |
| >TK1004c| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTXICDEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPELVI YQYMDDLYVGSDLEIGQHRAKIEKLRNHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPINLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |