<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK1004 TK1004 Denmark 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ NFV 59
2 D4T+ EFV+ IDV+ RTV 8
3 D4T+ EFV+ IDV+ RTV+ 3TC 64

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N   V35T, E36A, T39D, S48T, V60I, K122E, D123S, K173A, D177E, T200A, E204K, Q207N, R211K, V245S, A272P, K277R, E291D, V292I, I293V, H315X  
>TK1004| codons 1-319
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEKLRNHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPISLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVQGVYY

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I3IV, T12P, I15V, L19I, K20T, E21G, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74A, L89M, I93L  
>TK1004| codons 1-99
PQVTLWQRPLVPIKVGGQITGALLDTGADDTVLEDIDLPGKWKPRMIGGIGGFIKVRQYD
QIPLEICGKKAIGAVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005