Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1003 | TK1003a | Denmark | 2002 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV+ 3TC+ AZT | 81 |
| 2 | None | 4 |
| 3 | 3TC+ AZT+ RTV+ SQV | 1 |
| 4 | IDV+ 3TC+ AZT | 18 |
| 5 | None | 121 |
| 6 | ABC+ 3TC+ AZT+ EFV | 24 |
| 7 | None | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | V35T, T39LS, K49R, V60I, D121H, K122E, T200I, Q207G, R211K, P243S, V245K, A272P, K277R, L282C, L283I, I293V |
| >TK1003a| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQSIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, I15V, R41K, I62V, I64V, E65D, V77I |
| >TK1003a| codons 1-99 PQITLWQRPLVTVKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QVLVDICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |