Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1825 | CA4911 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+DDI | 117 |
| 3 | AZT+DDI+IDV | 9 |
| 4 | 3TC+D4T+NFV | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | E28EG, K43Q, V118I, K122KE, Q174R, I178IM, Q207E, R211K, A272P, E291D, A304G, N306X, G333E, Q334H, T338S, K390R, A400T, T403TM, D460N, V467VI, S519N, E529D, K530KR, I556V, K558R | E305GR |
| >CA4911| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTGEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDMVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE LELGGXREILKEPVHGVYYDPSKDLIAEIQKQEHGQWSYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVISLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKDRVYLAWVPAHK GIGGNEQVDKLVSAGVRRVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | Q58E, G73A | L10I, L63P, A71T, I72T, V77I, I93L |
| >CA4912| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVREYD QIPIEICGHKTTATVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |