Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DMP004-132 | 04-132162 | U.S. | 1995 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | NA |
| 2 | AZT+ 3TC+ EFV | 6 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, T69D, K70R, M184V, T215F | K219Q | L100I, K103N | K20R, K102R, K122E, D123E, I135T, G196E, L228H, R284RK, T286A, K311KR, I326V, Q334IV, R356K, G359S, A360T, T377LQ, K390R |
| >04-132162| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVIPLTEEAE LELAENREILREPVHGVYYDPSKDLVAEIQKQGIGQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, T12IK, I13V, G16E, M36I, I62V, L63A |
| >04-132162| codons 1-99 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Genotypic correlates of phenotypic resistance to Efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy. | J Virol, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |