<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1161 CA4884 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 156
2 AZT+ DDC 52
3 AZT+ DDI 52
4 D4T+ DDI 52
5 AZT+ DDC 52
6 3TC+ AZT+ DDC 43
7 3TC+ AZT+ D4T+ SQV 17
8 3TC+ AZT+ D4T+ RTV+ SQV 26
9 3TC+ AZT+ D4T+ DLV+ IDV 25
10 3TC+ D4T+ NFV 26
11 D4T+ DDI 30
12 D4T+ DDI+ EFV+ ADV 23

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74I, T215F T69G, K219Q L100I, K103N   E6D, K20R, T39N, K43E, D67X, K102R, D123E, K166R, D177E, V179I, G196K, T200I, Q207E, L228LR, V245K, A272P, K277R, I293V  
>CA4884| codons 1-302
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNELEEEGKISKIGPENPYNTPV
FAIKKKXSGRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIII
YQYMDDLYVGSDLEIKQHRIKIEELREHLLRWGFFTPDQKHQKEPPFRWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M K43KT, F53FL L10I, E34Q, I62V, L63A, A71V, T74S  
>CA4883| codons 10-99
IVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKMIGGIGGFVKVRQYDQVAIEICGH
KVIGSVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005