Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA1161 | CA4884 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 156 |
2 | AZT+ DDC | 52 |
3 | AZT+ DDI | 52 |
4 | D4T+ DDI | 52 |
5 | AZT+ DDC | 52 |
6 | 3TC+ AZT+ DDC | 43 |
7 | 3TC+ AZT+ D4T+ SQV | 17 |
8 | 3TC+ AZT+ D4T+ RTV+ SQV | 26 |
9 | 3TC+ AZT+ D4T+ DLV+ IDV | 25 |
10 | 3TC+ D4T+ NFV | 26 |
11 | D4T+ DDI | 30 |
12 | D4T+ DDI+ EFV+ ADV | 23 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, K70R, L74I, T215F | T69G, K219Q | L100I, K103N | E6D, K20R, T39N, K43E, D67X, K102R, D123E, K166R, D177E, V179I, G196K, T200I, Q207E, L228LR, V245K, A272P, K277R, I293V |
>CA4884| codons 1-302 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNELEEEGKISKIGPENPYNTPV FAIKKKXSGRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIII YQYMDDLYVGSDLEIKQHRIKIEELREHLLRWGFFTPDQKHQKEPPFRWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LE |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, V82A, L90M | K43KT, F53FL | L10I, E34Q, I62V, L63A, A71V, T74S |
>CA4883| codons 10-99 IVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKMIGGIGGFVKVRQYDQVAIEICGH KVIGSVLVGPTPANIIGRNLMTQIGCTLNF |
References
Author | Title | Citation |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |