Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1161 | CA4884 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | AZT+ DDC | 52 |
| 3 | AZT+ DDI | 52 |
| 4 | D4T+ DDI | 52 |
| 5 | AZT+ DDC | 52 |
| 6 | 3TC+ AZT+ DDC | 43 |
| 7 | 3TC+ AZT+ D4T+ SQV | 17 |
| 8 | 3TC+ AZT+ D4T+ RTV+ SQV | 26 |
| 9 | 3TC+ AZT+ D4T+ DLV+ IDV | 25 |
| 10 | 3TC+ D4T+ NFV | 26 |
| 11 | D4T+ DDI | 30 |
| 12 | D4T+ DDI+ EFV+ ADV | 23 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, T215F | T69G, K219Q | L100I, K103N | E6D, K20R, T39N, K43E, D67X, K102R, D123E, K166R, D177E, V179I, G196K, T200I, Q207E, L228LR, V245K, A272P, K277R, I293V |
| >CA4884| codons 1-302 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNELEEEGKISKIGPENPYNTPV FAIKKKXSGRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIII YQYMDDLYVGSDLEIKQHRIKIEELREHLLRWGFFTPDQKHQKEPPFRWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | K43KT, F53FL | L10I, E34Q, I62V, L63A, A71V, T74S |
| >CA4883| codons 10-99 IVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKMIGGIGGFVKVRQYDQVAIEICGH KVIGSVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |