Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1341 | CA48551 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDI | 100 |
| 3 | AZT+DDC | 40 |
| 4 | D4T | 26 |
| 5 | AZT | 38 |
| 6 | 3TC+AZT+IDV | 72 |
| 7 | 3TC+AZT+DLV+RTV+SQV | 38 |
| 8 | 3TC+ADV+AZT+EFV+NFV+SQV | 53 |
| 9 | ABC+ADV+EFV | 26 |
| 10 | ADV+APV+D4T+DDI | 29 |
| 11 | 3TC+APV+AZT | 18 |
| 12 | 3TC+APV+AZT+LPV | 86 |
| 13 | 3TC+APV+AZT+LPV+TDF | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, Q58E, G73A | L10I, V11L, G16A, L19I, R41K, K55R, D60E, I62V, L63P, I64M, A71I, I72M, V77I, I93L |
| >CA48551| codons 1-99 PQITLWQRPILTIKIAGQIKEALLDTGADDTVFEEMNLPGKWKPKLIGGIGGFVRVREYE QVPMEICGHKIMATVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103N | E6K, V35M, T39E, E44D, V111I, V118I, K122E, M164L, Q174R, G196E, Q197K, Q207E, R211K, Q278H, T286A, I293V |
| >CA48552| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSLTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIEKHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |