Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4908 | CA48444 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 109 |
| 2 | AZT+DDI | 61 |
| 3 | AZT+DDI+SQV | 61 |
| 4 | 3TC+AZT+NVP | 17 |
| 5 | 3TC+AZT+NFV | 26 |
| 6 | EFV+RTV+SQV | 20 |
| 7 | ABC+D4T+DDI | 32 |
| 8 | ABC+EFV+RTV+SQV | 31 |
| 9 | ABC+D4T+LPV | 82 |
| 10 | 3TC+ABC+LPV+TDF | 102 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, Y115F, M184V, L210W, T215Y | K219KN | V106A, G190A | V179D, F227L | K20KR, V35I, T39A, K43Q, V60VI, W88WCS, V118VI, D123E, Q174QR, D177E, V189I, G196E, I202V, R211K, T286A, I293IV, E297K |
| >CA48444| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQEGKISKIGPENPYNTPI FAIKKKNSTKWRKIVDFRELNKRTQDFSEVQLGIPHPAGLKKKKSATVLDVGDAFFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIDI YQYVDDLYIASDLEIEQHRTKVEELRQHLWKWGFYTPDNKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47IV, I54V, I84V, L90M | L10F, V11I, Q58E, G73S | I15V, G16A, L19LIPT, K20I, M36I, L63P, A71V, I72L, P79X, N83S, I85V, T91S |
| >CA48443| codons 1-99 PQITLWQRPFITIKVAGQTIEALLDTGADDTVLEEINLPGRWKPKMVGGIGGFVKVREYD QIPIEICGHKVLSTVLVGXTPVSVVGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |