<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5257 CA48431 U.S. 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 87
2 3TC+AZT+IDV 70
3 D4T+RTV 22
4 D4T+DDI+NVP 26
5 3TC+D4T+DDI+NFV 48
6 ABC+APV 26
7 D4T+DDI+EFV+IDV+RTV 83
8 ABC+APV+DDI 18
9 ABC+APV+DDI+TDF 136

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, K43T L10V, K20R, E35D, M36I, I62V, L63P, I64V, T74S  
>CA48431| codons 1-99
PQITLWQRPVVTIKIGGQLREALIDTGADDTVLEDINLPGRWTPKLIGGIGGFVKVRQYD
QVPVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LV, L210W, T215Y K219KNRS L100I, K103N   E6EK, K20KR, V35I, T39TA, K43KE, E44D, V118I, K122E, I135T, E169D, E203K, Q207E, R211K, K223KEQ, L228H, T286A, I293V  
>CA48432| codons 1-304
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDSKHQQEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELA

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005