Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5257 | CA48431 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | 3TC+AZT+IDV | 70 |
| 3 | D4T+RTV | 22 |
| 4 | D4T+DDI+NVP | 26 |
| 5 | 3TC+D4T+DDI+NFV | 48 |
| 6 | ABC+APV | 26 |
| 7 | D4T+DDI+EFV+IDV+RTV | 83 |
| 8 | ABC+APV+DDI | 18 |
| 9 | ABC+APV+DDI+TDF | 136 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, K43T | L10V, K20R, E35D, M36I, I62V, L63P, I64V, T74S |
| >CA48431| codons 1-99 PQITLWQRPVVTIKIGGQLREALIDTGADDTVLEDINLPGRWTPKLIGGIGGFVKVRQYD QVPVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, L210W, T215Y | K219KNRS | L100I, K103N | E6EK, K20KR, V35I, T39TA, K43KE, E44D, V118I, K122E, I135T, E169D, E203K, Q207E, R211K, K223KEQ, L228H, T286A, I293V |
| >CA48432| codons 1-304 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDSKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |