Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA21019 | CA48347 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+DDI | 22 |
| 3 | 3TC+D4T | 78 |
| 4 | 3TC+AZT+NVP | 22 |
| 5 | DDI+NFV | 78 |
| 6 | ABC+RTV+SQV | 237 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I84V, L90M | L33F, N88D | I13V, I15V, L63P, A71T |
| >CA48347| codons 1-99 PQITLWQRPLVTVKVGGQLKEALLDTGADNTVFEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPVNVIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K20KR, K43R, E44D, V60I, K122E, I135T, K154KE, R211K, A272AT, K277R, T286A |
| >CA48348| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELERDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWEGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVRQLCKLLRGAKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |