Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4771 | CA48253 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 61 |
| 2 | 3TC+AZT+IDV | 202 |
| 3 | D4T+EFV+RTV+SQV | 87 |
| 4 | 3TC+ABC+AZT | 81 |
| 5 | D4T+DDI+LPV+TDF | 87 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L10V, T12P, Q18M, I62IV, L63P, H69R, A71V, I72V, I93L |
| >CA48253| codons 1-99 PQITLWQRPVVPIKIGGMLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGRKVVGTVVVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70E, L210W, T215Y | V35T, T39A, K49R, S68R, V118VI, K122E, D123S, I135T, S162D, I178M, G196GR, T200A, R211K, V245T, E248D, R284RK, I293V, E297K | K66K_*TTKK |
| >CA48254| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISRIGPENPYNTPV FAIKKKDRTEWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIRQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |