Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1289 | CA48195 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 4 |
| 2 | D4T | 17 |
| 3 | 3TC+D4T | 9 |
| 4 | 3TC+D4T+SQV | 48 |
| 5 | 3TC+D4T+NFV | 25 |
| 6 | 3TC+D4T+RTV+SQV | 255 |
| 7 | 3TC+RTV+SQV+TDF | 15 |
| 8 | 3TC+RTV+SQV | 10 |
| 9 | DDI+EFV+LPV+TDF | 2 |
| 10 | None | 14 |
| 11 | Unknown | 46 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | V11I, K43T, G73S | L10I, I15V, L19P, K20I, M36MI, N37D, R57RK, I62V, L63P, A71V, P79S |
| >CA48195| codons 1-99 PQITLWQRPIITIKVGGQPIEALLDTGADDTVLEEIDLPGRWTPKMIGGIGGFLKVKQYD QVPIEICGHKVISTVLVGSTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, M184V | K219Q | K20R, V35I, I142IV, S162N, K166KQR, D218DE, L228LH, K277R, I293IV, K311KR, V317VA, Q334R, G335D, P345Q, M357T, G359S |
| >CA48196| codons 1-371 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGAYYDPSKDLIAEIQKQGRDQWTYQIYQEQFKNLKTGKYARTRSA HTNDVKQLTEA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |