Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2204 | CA48186 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 100 |
| 2 | AZT+DDI+NFV | 39 |
| 3 | 3TC+D4T+NVP | 87 |
| 4 | 3TC+D4T+IDV | 72 |
| 5 | 3TC+ABC+APV+D4T | 37 |
| 6 | APV+D4T+DDI+RTV | 43 |
| 7 | 3TC+APV+D4T+RTV+TDF | 18 |
| 8 | 3TC+ABC+AZT+EFV+TDF | 106 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K101P, K103N, G190A | V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196E, R211K, Q278H, T286A, I293V, E297R | K13N, H221DY |
| >CA48186| codons 1-302 PISPIETVPVKLNPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQNFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTREAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10I, R41K, I62V, L63P, I93L |
| >CA48185| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |