Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1829 | CA48176 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 41 |
| 2 | AZT+D4T+DDC | 52 |
| 3 | 3TC+D4T | 39 |
| 4 | 3TC+IDV | 32 |
| 5 | 3TC+DLV+NFV | 65 |
| 6 | ADV+IDV+NFV+SQV | 28 |
| 7 | ABC+ADV+IDV+NFV+SQV | 11 |
| 8 | ABC+ADV | 20 |
| 9 | None | 35 |
| 10 | 3TC+ABC+EFV+RTV+SQV | 96 |
| 11 | 3TC+EFV+RTV+SQV | 78 |
| 12 | 3TC+ATV+EFV+RTV | 29 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W | A62V, D67E, T215C | K103N, Y181C | V108I | K20R, K122E, D177E, L228H, V245E, A272P, I293V, E297K | S68S_SV |
| >CA48176| codons 1-299 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKESTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFCTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36I, I62V, L63S, V82I |
| >CA48175| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVSIEICGHKAIGTVLVGPTPINIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |