Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5593 | CA48174 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 74 |
| 2 | 3TC+AZT+SQV | 126 |
| 3 | D4T+NFV+NVP | 65 |
| 4 | D4T+DDI+IDV+RTV | 52 |
| 5 | 3TC+AZT+IDV+RTV | 37 |
| 6 | None | 63 |
| 7 | ABC+D4T+LPV+TDF | 73 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | D67G, K219HQ | Y181C | K20R, T69N, K102R, R211A, F214L, L228R, K277R, R284K, T286A, I293V, P294S, E297R |
| >CA48174| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLAWGLTTPDQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVVSLTREAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, K14R, K55R, I62V, L63P, A71V, I72L, V77I, P79A, I93L |
| >CA48173| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD QVPIEICGHKVLSTVLIGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |