Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1144 | CA48172 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 57 |
| 3 | AZT+DDI | 8 |
| 4 | AZT+DDC | 35 |
| 5 | 3TC+D4T | 13 |
| 6 | AZT+D4T+RTV+SQV | 57 |
| 7 | AZT+D4T+RTV+SQV | 31 |
| 8 | 3TC+D4T+NFV | 17 |
| 9 | 3TC+D4T+NFV+NVP | 52 |
| 10 | 3TC+D4T+NFV+NVP | 26 |
| 11 | 3TC+D4T+IDV+RTV | 233 |
| 12 | 3TC+IDV+RTV+TDF | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | V35M, V118I, K122E, I135T, S162AD, V179I, I202V, F214L, L228H, A272P, K277R, A288AT |
| >CA48172| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54A, V82AT, L90M | Q58E | L10V, T12TK, L19I, F53Y, D60DE, Q61E, I62V, L63P, A71V, I72V, T74S, V77I, I93L | Q18Q*HY |
| >CA48171| codons 1-99 PQITLWQRPVVKIKIGGYIKEALLDTGADDTVLEEMNLPGRWKPKLIVGIGGYAKVREYE EVPIEICGHKVVGSVLIGPTPTNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |