Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4164 | CA48165 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 52 |
| 2 | 3TC+AZT+NFV | 52 |
| 3 | D4T+DDI+NVP+RTV | 71 |
| 4 | 3TC+AZT+IDV+RTV | 22 |
| 5 | 3TC+APV+AZT+RTV | 13 |
| 6 | AZT+DDI+IDV+SQV | 13 |
| 7 | 3TC+DDI+TDF | 52 |
| 8 | 3TC+ATV+DDI+RTV+TDF | 42 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54V | L10F, G73S, N88D | I13V, I15V, K20T, E35D, M36I, N37D, I62V, L63P, V77I, I93L |
| >CA48165| codons 1-99 PQITLWQRPFVTVKVGGQLTEALLDTGADNTVLEDIDLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKAISTVLIGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, M184V | V179E | S68G, R83RK, K102R, K122KE, S163T, K173N, Q174K, D177G, Q207E, R211K, V245T, E248ED, A272P, R284K, T286A, I293V |
| >CA48166| codons 1-296 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSTMTKILEPFRNKNPGIEI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVPLT |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |