Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1579 | CA48131 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 134 |
| 2 | 3TC+AZT | 63 |
| 3 | D4T+DDI+IDV | 16 |
| 4 | 3TC+AZT+IDV | 16 |
| 5 | D4T+DLV+RTV+SQV | 53 |
| 6 | 3TC+D4T+DDI+NFV+NVP | 55 |
| 7 | APV+D4T+DDI+NVP | 16 |
| 8 | APV+D4T+DDI+RTV | 83 |
| 9 | 3TC+ABC+APV+D4T+DDI+RTV | 48 |
| 10 | 3TC+ABC+APV+D4T+DDI+RTV+TDF | 31 |
| 11 | 3TC+ABC+ATV+D4T+DDI+RTV+TDF | 66 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, I84AV | L10I, N37D, L63P, H69Y, A71V, V77I, I93L |
| >CA48131| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIVGIGGFVKVRQYD QIPIEICGYKVIGTVLIGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, L210W, T215Y | M230L | F227L | K20R, K43KE, S48SL, K122E, I135IV, E138G, D177E, I178L, R211K, H221C, L228R, V245M |
| >CA48132| codons 1-251 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEEGKILKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNGTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKCQKEPPLRWLGYELHPDKWT VQPIMLPEKDS |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |