Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6585 | CA48124 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 6 |
| 2 | D4T+DDI+RTV+SQV | 17 |
| 3 | ABC+EFV+NFV+NVP | 41 |
| 4 | 3TC+APV+AZT+RTV | 37 |
| 5 | 3TC+D4T+LPV+NVP | 76 |
| 6 | D4T+DDI+TDF | 17 |
| 7 | 3TC+ABC+AZT+DLV+SQV+T20 | 11 |
| 8 | 3TC+AZT+DLV+SQV+T20 | 70 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69AD, M184MV, L210W, T215Y | K219KR | Y188L | A98AG | S3A, K20KR, V35I, T39A, K43Q, E44D, V118I, K122E, I135T, V179VI, G196E, T200A, E203K, Q207E, H208FY, R211K, H221HL, K223Q, V245E |
| >CA48124| codons 1-249 PIAPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLLVGSDLEIEQHRAKIKELREYLWKWGFYTPDRKLQQEPPFLWMGYELHPDKWT VQPIELPEK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I47V, I54M, V82A, L90M | L33F, K43T, G73S, L89V | L10V, T12D, I13V, I15V, K20M, E35ED, M36ML, D60E, Q61DN, I62V, L63P, C67Y, H69K, A71I, I72L, V77I |
| >CA48123| codons 1-99 PQITLWQRPVVDVKVGGQLMEALLDTGADDTIFEDLNLPGRWTPKIVGGIGGFMKVRQYE NVPIEIYGKKILSTVLIGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |