Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1420 | CA48114 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 59 |
| 2 | DDC | 71 |
| 3 | D4T | 25 |
| 4 | D4T+ SQV | 6 |
| 5 | D4T+ 3TC+ SQV | 3 |
| 6 | D4T+ 3TC+ RTV+ NVP | 23 |
| 7 | D4T+ RTV+ 3TC+ IDV | 13 |
| 8 | D4T+ 3TC+ IDV | 40 |
| 9 | D4T+ NFV+ 3TC | 17 |
| 10 | D4T+ NFV+ 3TC+ SQV | 11 |
| 11 | D4T+ NFV | 6 |
| 12 | D4T+ NFV | 47 |
| 13 | DDI+ 3TC+ APV | 39 |
| 14 | D4T+ DDI+ EFV+ APV + RTV | 47 |
| 15 | None | 78 |
| 16 | ABC+ D4T+ FTC+ TDF | 101 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, M184V, L210W, T215Y | K219N, N348I | L100LI, K103N, Y181YC, G190GA | A98AG, V179VF | K20R, K43N, E44D, V118I, K122E, G196E, T200TA, E203EK, E204EK, Q207E, R211K, L228H, A272P, I293V, E297A, I329L, M357T, G359S |
| >CA48114| codons 1-368 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI CQYVDDLYVASDLEIEQHRAKIKKLREHLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARTRSA HTNDVKQL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84V, L90M | L33F, G73GS | L10I, I13IV, K20X, E35D, M36L, N37D, I62V, L63P, C67F, G68GE, H69HQ, A71IV, I72IM |
| >CA48113| codons 1-99 PQITLWQRPIVTVKIGGQLXEALLDTGADDTVFEDLDLPGRWKPKMIGGIGGFVKVRQYD QVPIEIFEQKVMSTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |