Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5058 | CA48110 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+DDC | 47 |
| 3 | 3TC+D4T | 65 |
| 4 | 3TC+D4T+NFV | 91 |
| 5 | 3TC+D4T+IDV | 30 |
| 6 | 3TC+D4T+RTV+SQV | 21 |
| 7 | 3TC+EFV+IDV | 104 |
| 8 | 3TC+EFV+IDV+TDF | 74 |
| 9 | 3TC+ABC+EFV+IDV+TDF | 49 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, T215Y | K101P, K103N | V35L, T39A, R83K, A98S, D123N, S162F, V179I, D192N, E204Q, H208Y, L210S, R211K, H221Y, D250E, V261VG, A272P, T286A, A288P, E297R, Q334E, G359S |
| >CA48110| codons 1-363 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKKTQDFWEVQLGIPHPSGLPKNKSVTVLDVGDAYFSVPL DKNFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPDIII YQYVDDLYVGSNLEIGQHRTKIEQLRQYLSKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLGGKLNWASQIYPGIKVKQLCKLLRGAKPLTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRSA HTN |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | L10V, E35D, L63S, I64V, H69R, A71V, I72V, I93L |
| >CA48109| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPKIIGGIGGFIKVRQYD QISVEICGRKVVTTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |