Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1290 | CA48090 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 22 |
| 2 | D4T | 35 |
| 3 | 3TC+AZT+SQV | 13 |
| 4 | 3TC+AZT+IDV | 48 |
| 5 | 3TC+AZT+DDI+NFV+NVP | 18 |
| 6 | 3TC+AZT+IDV | 26 |
| 7 | D4T+RTV+SQV | 30 |
| 8 | D4T+NFV+RTV+SQV | 18 |
| 9 | ABC+D4T+NFV+RTV+SQV | 22 |
| 10 | ABC+APV+D4T+NFV+RTV+SQV | 26 |
| 11 | 3TC+APV+D4T+NFV+RTV+SQV | 170 |
| 12 | None | 35 |
| 13 | 3TC+APV+RTV+SQV | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215F | K219Q | K103S | V118I, K122E, I178IM, V179VI, T200A, Q207EK, D218E, D250DA, A272P, T286TA, E297A |
| >CA48090| codons 2-301 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVF AIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPLD EDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMIIY QYVDDLYVGSDLEIGQHRAKIEELRKHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWTV QPIVLPEKASWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, V82A, L90M | L23I, L33F, K43T, F53L, G73T | L10I, I15V, Q18H, K20R, E35D, M36I, N37D, K55R, D60E, L63P, I64V, C67F, H69K, I72IV, I93L |
| >CA48089| codons 1-99 PQITLWQRPIVTIKVGGHLREAILDTGADDTVFEDIDLPGRWTPKIIGGIGGLMRVRQYE QIPVEIFGKKAVTTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |