Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6583 | CA48088 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT | 9 |
| 3 | 3TC+AZT+SQV | 22 |
| 4 | 3TC+AZT+IDV | 104 |
| 5 | AZT+RTV+SQV | 30 |
| 6 | 3TC+ABC+EFV | 65 |
| 7 | APV+D4T+RTV | 35 |
| 8 | 3TC+AZT+LPV+NVP | 48 |
| 9 | APV+EFV+IDV+TDF | 35 |
| 10 | AZT+EFV+IDV+LPV | 52 |
| 11 | 3TC+D4T+EFV+LPV+TDF | 33 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184MV, L210W, T215Y | V75VA, K219KN | K103N, Y181C, G190GA | V108I | V35VI, K43N, A98S, V118VI, D177N, G196E, Q207H, H208HY, R211K, H221Y, A272S, T286A, E297K |
| >CA48088| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKIADFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI CQYVDDLYVASDLEIEQHRTKIEELRHYLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54IL, L90LM | L10F, L33LF, G73GA | R41KT, L63P, A71T, I72IR, V77I, I93L | G78GR |
| >CA48087| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTIFEEMNLPGTWKPKIVGGIGGFLKVRQYD QIPIEICGHKTRATVLIRPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |