Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1130 | CA48079 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | D4T | 32 |
| 3 | 3TC+ AZT | 56 |
| 4 | SQV+ RTV+ D4T+ 3TC | 267 |
| 5 | 3TC+ ABC+ EFV+ TDF | 23 |
| 6 | 3TC+ ABC+ AZT+ TDF | 21 |
| 7 | 3TC+ ABC+ D4T+ TDF | 13 |
| 8 | Unknown | 55 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90LM | L33F, G73T | L10I, T12S, I13V, R41RK, L63P, A71V, V77I, I93L |
| >CA48079| codons 1-99 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVFEEMNLPGKWKPKMIGGIGGFLKVRQYD QIPIEICGHKVITTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, M184V, L210W, T215Y | K219Q | A98AG | E40X, K43E, E44EA, K64H, T69N, K122E, D123E, S162SN, Q174K, D177E, I178M, V179VI, Q207E, H208Y, R211K, L228H, Q242QH, A272P, I293IV |
| >CA48080| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTXLEEAGKISKIGPENPYNTPV FAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKKNPEMII YQYVDDLYVGSDLEIGQHRTKIEELREYLWKWGFYTPDQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |