<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AC_Pat40 RO.00.IS.40 Romania 2000 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 IDV+ 3TC+ AZT NA
2 None NA
3 IDV+ EFV+ 3TC NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A   L10V, I15V, G17E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M  
>RO.00.IS.40| codons 1-99
PQITLWQRPVVTIKVGEQLREALLDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVKQYD
QITIDICGHKATGTVLVGPTPANIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R K219Q K103N P225H T39A, I135L, S162Y, K173T, Q174K, I195L, T200A, Q207T, R211K  
>RO.00.IS.40| codons 33-239
ALVEICAEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQL
GIPHPAGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQG
WKGSPAIFQYSMTKILEPFRTKNPDIVIYQYMDDLYVGSDLELGQHRAKIEELRTHLLKW
GFTTPDQKHQKEHPFLWMGYELHPDKW

References
Author Title Citation
Apetrei, C HIV type 1 diversity in northeastern Romania in 2000-2001 based on phylogenetic analysis of pol sequences from patients failing antiretroviral therapy. ARHR, 2003