<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AC_Pat36 RO.00.IS.36 Romania 2000 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 IDV+ 3TC+ AZT NA
2 None NA
3 NVP+ RTV+ D4T NA
4 NFV+ SQV+ 3TC NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R   K103N   V35T, T39A, E40D, D123E, I135L, S162Y, K173I, Q174K, T200A, Q207E, R211K Y232H
>RO.00.IS.36| codons 33-239
ALTEICADMEKEGKISKIGPENPYNTPVFAIKKKDSTRWRKLVDFRELNKRTQDFWEVQL
GIPHPAGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSLNNETPGIRYQYNVLPQG
WKGSPAIFQYSMTKILEPFRIKNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELREHLLKW
GFTTPDKKHQKEPPFLWMGHELHPDKW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A   L10V, T12I, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, K70E, I72T, L89M  
>RO.00.IS.36| codons 1-99
PQITLWQRPVVIVKVEGQLREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD
QVTIDICGHEATGTVLVGPTPANIIGRNMLTQIGCTLNF

References
Author Title Citation
Apetrei, C HIV type 1 diversity in northeastern Romania in 2000-2001 based on phylogenetic analysis of pol sequences from patients failing antiretroviral therapy. ARHR, 2003