<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
AC_Pat25 RO.01.IS.25 Romania 2001 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 IDV+ 3TC+ AZT NA
2 None NA
3 IDV+ EFV+ D4T NA
4 IDV+ D4T NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, V82A   L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T  
>RO.01.IS.25| codons 1-99
PQITLWQRPVVTIKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFIKVKQYD
QITIDICGHKATGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N P225H V35T, T39A, W88C, K101Q, D123E, I135L, E138G, S162H, K166Q, Q174R, D177E, I195L, G196K, T200A, Q207A, R211K  
>RO.01.IS.25| codons 33-239
ALTEICAEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFCEVQL
GIPHPAGLQKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSLNNGTPGIRYQYNVLPQG
WKGSPAIFQHSMTQILEPFRKRNPEIVIYQYMDDLYVGSDLELKQHRAKIEELRAHLLKW
GFTTPDKKHQKEHPFLWMGYELHPDKW

References
Author Title Citation
Apetrei, C HIV type 1 diversity in northeastern Romania in 2000-2001 based on phylogenetic analysis of pol sequences from patients failing antiretroviral therapy. ARHR, 2003