Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patROUG | 01_ROUG729 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 126 |
| 2 | AZT+ DDI | 4 |
| 3 | DDI | 4 |
| 4 | None | 313 |
| 5 | 3TC+ ABC+ AZT+ NFV | 52 |
| 6 | 3TC+ ABC+ AZT+ NVP | 69 |
| 7 | Unknown | 31 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73T | L10I, D60E, Q61E, I62V, L63P, I64V, I66L, I93L |
| >01_ROUG729| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYE EVPVELCGHKAITTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N, Y181C | K20R, K43E, E44A, K49R, D121Y, K122E, I135T, D177E, T200I, E204K, R211Q, L228R |
| >01_ROUG729| codons 1-239 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRIKIEKLRQHLWQWGFYTPDKKHQKEPPFRWMGYELHPDKW |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |