Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patLEF | 01_LEF703 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+ 3TC | 104 |
| 3 | RTV+ D4T+ 3TC | 65 |
| 4 | None | 17 |
| 5 | NFV+ AZT+ 3TC | 17 |
| 6 | SQV+ RTV+ DDI+ ABC | 17 |
| 7 | NVP+ DDI+ ABC | 34 |
| 8 | DDI+ ABC | 5 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219E | Y181C | V35I, D121Y, K122E, D177E, H221Y |
| >01_LEF703| codons 1-239 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDEKYQKEPPFLWMGYELHPDKW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A, L90M | L10I, L19I, N37S, F53I, I62V, L63P, H69Q |
| >01_LEF703| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGIIKVRQYD QVPIEICGQKAIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |