Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patLEC | 01_LECS714 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 160 |
| 2 | DDI | 26 |
| 3 | SQV+ DDI+ D4T | 13 |
| 4 | IDV+ AZT+ 3TC | 213 |
| 5 | NVP+ NFV+ DDI | 82 |
| 6 | None | 8 |
| 7 | SQV+ RTV+ AZT+ 3TC | 39 |
| 8 | LPV+ AZT+ 3TC | 21 |
| 9 | LPV+ ABC+ 3TC | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | K43T | L10I, Q18H, L19I, N37S, Q61N, I62V, I64V, A71T, I72V, T74S, V77I, I93L |
| >01_LECS714| codons 1-99 PQITLWQRPIVTIKIGGHIKEALLDTGADDTVLEEMSLPGRWTPKMIVGIGGFVKVRQYD NVLVEICGHKTVGSVLIGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | A98G | P4S, V118I, D123E, S162D, K166R, D177E, V179I, I202V, R211K, F214L, L228H |
| >01_LECS714| codons 1-240 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPEIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWT |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |