Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patDEP | 01_DEP716 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ AZT | 47 |
| 2 | AZT+ 3TC | 30 |
| 3 | DDI+ D4T+ 3TC | 87 |
| 4 | NFV+ AZT+ 3TC | 104 |
| 5 | NFV+ AZT | 27 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K122E, D123N, I135L, S162C, I195L, L210F |
| >01_DEP716| codons 1-245 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLELGQHRTKIEELRQHLFRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10F, N88D | E35D, M36I, R57K, I62V, L63P, H69Q |
| >01_DEP716| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGQKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |