Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMIC | 01_MICA510 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 169 |
| 2 | 3TC+ D4T+ RTV | 26 |
| 3 | 3TC+ D4T+ IDV | 26 |
| 4 | D4T+ DDI+ RTV+ SQV | 30 |
| 5 | D4T+ DDI+ NFV | 4 |
| 6 | NFV+ NVP+ SQV | 17 |
| 7 | ABC+ NFV | 13 |
| 8 | DDI | 8 |
| 9 | 3TC+ D4T+ RTV+ SQV | 17 |
| 10 | 3TC+ AZT+ DDI | 21 |
| 11 | 3TC+ DDI+ SQV | 17 |
| 12 | 3TC+ AZT+ SQV | 21 |
| 13 | 3TC+ RTV+ SQV | 4 |
| 14 | 3TC+ AZT+ SQV | 4 |
| 15 | 3TC+ DDI+ LPV | 26 |
| 16 | 3TC+ DDI | 4 |
| 17 | None | 8 |
| 18 | 3TC+ APV+ DDI+ RTV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, T74S, V77I |
| >01_MICA510| codons 1-98 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVIGSVLIGPTPANIIGRNLMTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219R | K103N, Y181C | E44D, V118I, K122E, I142V, E203K, H208Y, R211K, K223Q | V10E |
| >01_MICA510| codons 1-240 PISPIETVPEKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYIDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |