Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMAK | 01_MAK707 | France | 2001 | HIV1 | CRF11_cpx | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 35 |
| 2 | DDI+ AZT | 22 |
| 3 | DDI | 9 |
| 4 | 3TC | 12 |
| 5 | DDI+ D4T | 4 |
| 6 | DDI+ D4T+ 3TC | 20 |
| 7 | SQV+ RTV | 47 |
| 8 | SQV+ NFV | 13 |
| 9 | SQV | 1 |
| 10 | SQV+ AZT+ 3TC | 31 |
| 11 | SQV+ RTV+ AZT+ 3TC | 90 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | V32G, F53L | L10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, T74A, L89M |
| >01_MAK707| codons 1-99 PQITLWQRPIVTVRIGEQLIEALLDTGADDTGLEDINLPGKWKPKMIGGIGGLVKVRQYD QIPIEICGKKAIGAVLVGPTPVNVIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | V35T, T39N, E40D, V60I, I135T, K173T, D177E, T200A, Q207K, D218E |
| >01_MAK707| codons 1-240 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNDMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRKHLLRWGFTTPEQKHQKEPPFLWMGYELHPDKWT |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |