Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patBRI | 01_BRI705 | France | 2001 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 61 |
| 2 | None | 26 |
| 3 | DDI | 21 |
| 4 | D4T+ 3TC | 26 |
| 5 | SQV+ D4T+ 3TC | 82 |
| 6 | NFV+ AZT+ 3TC | 17 |
| 7 | SQV+ RTV+ AZT+ 3TC | 12 |
| 8 | NVP+ AZT+ 3TC | 1 |
| 9 | AZT+ 3TC | 7 |
| 10 | NVP+ AZT+ 3TC | 21 |
| 11 | DDI+ AZT+ 3TC | 34 |
| 12 | LPV+ DDI+ D4T | 8 |
| 13 | LPV+ DDI+ D4T+ 3TC | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L33F, F53L, T74P | L10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, H69K, K70R, L89M |
| >01_BRI705| codons 1-99 PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDIDLPGKWKPKMIGGIGGLVRVKQYD QILIEICGKRAIGPVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | G190A | A98G | E6D, K11T, V35I, T39R, K43E, E44D, S68G, V118I, K122E, D123S, K173T, Q174K, D177E, V179I, T200A, E203K, Q207D, L228H |
| >01_BRI705| codons 1-242 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALIEICRELEEDGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIII YQYVDDLYVASDLEIGQHRAKIKELRDHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQ |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |