Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMOR | 02_MOR735 | France | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 256 |
| 2 | DDI | 4 |
| 3 | DDI+ SQV | 17 |
| 4 | 3TC+ D4T+ SQV | 13 |
| 5 | 3TC+ D4T+ IDV | 21 |
| 6 | D4T+ SQV | 4 |
| 7 | D4T+ NFV+ SQV | 39 |
| 8 | D4T+ EFV+ NFV+ SQV | 52 |
| 9 | ABC+ RTV+ SQV | 21 |
| 10 | None | 13 |
| 11 | ABC+ D4T+ IDV+ RTV | 8 |
| 12 | ABC+ D4T | 12 |
| 13 | ABC+ NFV | 8 |
| 14 | None | 39 |
| 15 | 3TC+ LPV | 49 |
| 16 | 3TC | 2 |
| 17 | Unknown | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, G73S | K20I, E35G, M36I, I62V, L63P, A71T, I85V | I93N |
| >02_MOR735| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKTISTVLVGPTPVNVVGRNLMTQNGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K101P, G190A | V35M, T39K, K43E, E44D, V90I, V118I, D121H, K122E, K166R, F171Y, Q207E, R211K, L228H |
| >02_MOR735| codons 1-237 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICKELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPYRKQNPDIVI YQYIDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPD |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |