Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMOL | 02_MOLI735 | France | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI+ AZT | 35 |
| 3 | AZT+ 3TC | 65 |
| 4 | SQV+ DDC+ AZT | 56 |
| 5 | RTV+ DDI+ D4T | 17 |
| 6 | IDV+ DDI+ D4T | 52 |
| 7 | NVP+ DDI+ D4T | 20 |
| 8 | NVP+ DDI+ D4T+ AZT+ 3TC | 1 |
| 9 | NVP+ DDI+ D4T | 3 |
| 10 | NVP+ NFV+ DDI+ D4T | 18 |
| 11 | NVP+ DDI+ D4T | 30 |
| 12 | AZT+ ABC+ 3TC | 101 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I15V, L63P |
| >02_MOLI735| codons 1-99 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | A98G | E44D, V118I, K122E, I135T, T165I, G196E, E203K, R211K, K223Q |
| >02_MOLI735| codons 1-242 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIKELRQHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQ |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |