Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMASS | 00_MASS701 | France | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ AZT | 52 |
| 2 | SQV+ AZT+ 3TC | 21 |
| 3 | SQV+ RTV+ D4T+ 3TC | 47 |
| 4 | SQV+ NFV+ AZT+ 3TC | 21 |
| 5 | SQV+ NFV+ DDI+ D4T | 43 |
| 6 | SQV+ NVP+ NFV+ D4T | 8 |
| 7 | SQV+ NFV+ D4T+ 3TC | 73 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, I84V, L90M | L10I, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71V, Q92K |
| >00_MASS701| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKLIGGIGGFLKVRQYD QVPIEICGHKVIGTVLVGPTPVNVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K20R, K43E, V118I, D123E, S162Y, T200A, E203D, H208Y, R211K |
| >00_MASS701| codons 1-242 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQ |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |