Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patBELLE | 01_BELA701 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 73 |
| 2 | SQV+ D4T+ 3TC | 82 |
| 3 | SQV+ RTV | 39 |
| 4 | SQV+ NFV+ 3TC | 39 |
| 5 | SQV+ NVP+ NFV+ ABC+ 3TC | 30 |
| 6 | AZT+ ABC+ 3TC | 21 |
| 7 | NFV+ AZT+ ABC+ 3TC | 13 |
| 8 | EFV+ APV+ ABC+ 3TC | 8 |
| 9 | ABC+ 3TC | 39 |
| 10 | DDI+ ABC+ 3TC | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K101E, Y181C, G190A | A98G | I178M, H208Y, R211K, D218E, L228H |
| >01_BELA701| codons 1-238 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYVDDLYVASDLEIGQHRTKIEELRQYLLKWGFFTPEQKHQKEPPFHWMGYELHPDK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, E35D, N37D, L63P, I93L |
| >01_BELA701| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |