Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patMICH | 01_MICL706 | France | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | LPV| IDV| EFV| DDI| DDC| D4T| AZT| 3TC | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, M184V, T215F | K219Q | Y188L | V179D | E6K, K20R, V35M, T39A, V60I, K102E, K103R, V118I, K122E, I135T, S162Y, Q207E, R211K, F214L, D218E, K238R |
| >01_MICL706| codons 1-239 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKERKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIDI YQYVDDLLVGSDLEIGQHRTKIEELREHLLKWGLFTPEQKHQKEPPFLWMGYELHPDRW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E, G73C | I15V, Q18E, L19I, M36L, L38W, I62V, L63P, A71T, I72T, I85V, Q92K |
| >01_MICL706| codons 1-99 PQITLWQRPLVTIKVGGEIKEALLDTGADDTVLEELNWPGRWKPKLIGGIGGFVKVREYD QVPIEICGHKTTCTVLVGPTPANIVGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |