Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patFRE | 00_FRE705 | France | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | DDI+ AZT | 60 |
| 3 | DDC+ AZT | 17 |
| 4 | None | 26 |
| 5 | SQV+ DDI+ D4T | 21 |
| 6 | None | 30 |
| 7 | NFV+ D4T+ 3TC | 73 |
| 8 | NFV+ D4T+ ABC | 34 |
| 9 | NFV+ DDI+ D4T | 34 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V75T, Y115F, M184V | K11R, E53D, V118I, D123E, I135T, S162Y, T200I, R211G, F214L |
| >00_FRE705| codons 1-242 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLLGWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | I15V, E35G, M36I, N37D, L63P, V75I, I93L |
| >00_FRE705| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADNTVLEGIDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTILVGPTPVNIIGRDLLTQLGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |