Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MB_patTERR | 02_TERR707 | France | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 34 |
| 2 | RTV+ DDI+ AZT | 21 |
| 3 | IDV+ AZT+ 3TC | 17 |
| 4 | SQV+ RTV+ AZT+ 3TC | 21 |
| 5 | SQV+ RTV+ DDI+ D4T | 4 |
| 6 | SQV+ RTV+ D4T+ 3TC | 17 |
| 7 | SQV+ D4T+ 3TC | 17 |
| 8 | SQV+ NFV+ D4T+ 3TC | 8 |
| 9 | SQV+ NVP+ NFV+ D4T | 17 |
| 10 | SQV+ NFV+ D4T | 8 |
| 11 | D4T | 21 |
| 12 | None | 69 |
| 13 | EFV | 43 |
| 14 | NVP | 7 |
| 15 | NVP+ LPV | 5 |
| 16 | LPV+ 3TC | 58 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | Y188L, G190A | V35I, T39A, E44D, G45E, K101Q, V118I, D123E, V179I, I202V, E203D, H208Y, R211K | L12G |
| >02_TERR707| codons 1-239 PISPIETVPVKGKPGMDGPKVKQWPLTEEKIKALIEICAELEKDEKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLLVASDLEIGQHRTKVDELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPDKW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48A, I54V, V82A, L90M | L10I, K20R, E35D, M36I, N37E, I62V, L63S, I64M, A71V, I93L |
| >02_TERR707| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKLIAGIGGFVKVRQYD QVSMEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Montes, B | Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B. | JAIDS, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |